The BAH domain of BAHD1 is a histone H3K27me3 reader
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چکیده
منابع مشابه
The Taf14 YEATS domain is a reader of histone crotonylation
The discovery of new histone modifications is unfolding at startling rates; however, the identification of effectors capable of interpreting these modifications has lagged behind. Here we report the YEATS domain as an effective reader of histone lysine crotonylation, an epigenetic signature associated with active transcription. We show that the Taf14 YEATS domain engages crotonyllysine via a un...
متن کاملThe BAH domain of Rsc2 is a histone H3 binding domain
Bromo-adjacent homology (BAH) domains are commonly found in chromatin-associated proteins and fall into two classes; Remodels the Structure of Chromatin (RSC)-like or Sir3-like. Although Sir3-like BAH domains bind nucleosomes, the binding partners of RSC-like BAH domains are currently unknown. The Rsc2 subunit of the RSC chromatin remodeling complex contains an RSC-like BAH domain and, like the...
متن کاملHuman BAHD1 promotes heterochromatic gene silencing.
Gene silencing via heterochromatin formation plays a major role in cell differentiation and maintenance of homeostasis. Here we report the identification and characterization of a novel heterochromatinization factor in vertebrates, bromo adjacent homology domain-containing protein 1 (BAHD1). This nuclear protein interacts with HP1, MBD1, HDAC5, and several transcription factors. Through electro...
متن کاملStructure and function of the BAH domain in chromatin biology.
Proteins containing Bromo Adjacent Homology (BAH) domain are often associated with biological processes involving chromatin, and mutations in BAH domains have been found in human diseases. A number of structural and functional studies have revealed that the BAH domain plays diverse and versatile roles in chromatin biology, including protein-protein interactions, recognition of methylated histon...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2016
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-016-0243-z